First Generation vs. Second Generation Antihistamines 💊🌷🤧 You might be thinking… but aren’t they all basically the same? They’re actually not! 1st Generation → medications like diphenhydramine cross the blood-brain barrier. → These are often used for allergic reactions, rashes and pruritis, or exacerbation of seasonal allergies. → These can cause drowsiness since they do cross the blood-brain barrier, so are also used in some instances to aid in anxiety and sleep 2nd Generation → these includ
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