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The SCALE Kids trial, summarized here by NEJM Editorial Fellow Harleen Marwah, MD, assessed the efficacy and safety of liraglutide, as compared with placebo, as an adjunct treatment to lifestyle interventions, for the treatment of obesity in children 6 to 12 years of age. Full trial results: https://nej.md/3MBP1uc | The New England Journal of Medicine
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When GLP-1 RA medications for weight loss are stopped, significant weight regain occurs, typically with patients regaining 50-70% of their lost weight within one year. Weight regain begins rapidly—within weeks of discontinuation—at a rate of approximately 0.55% of original body weight per month. The magnitude of weight regain is proportional to the amount originally lost. In meta-analyses, patients who discontinued liraglutide regained 2.20 kg, while those stopping semaglutide or tirzepatide reg
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