Sep 7, 2020 · Mechanism of Action. Trazodone is an antidepressant that inhibits serotonin transporter and serotonin type 2 receptors; it is a triazolopyridine derivative. Trazodone inhibits …

Dec 31, 2015 · Trazodone is a serotonin uptake inhibitor used to treat major depressive disorder.

Data from open and double-blind trials suggest that the antidepressant efficacy of trazodone is comparable to that of amitriptyline, doxepin, and mianserin. Furthermore, trazodone has …

Mar 24, 2025 · Understanding the mechanism of action (MOA) of trazodone can provide insights into its effectiveness, potential benefits, and possible side effects. This article will explore the …

In this narrative review, we have summarized recent clinical trials and real-world data on trazodone, including the recently introduced once-daily formulation, which has single dose …

Feb 17, 2020 · Inhibits reuptake of serotonin, causes adrenoreceptor subsensitivity, acts as a 5HT 2a receptor antagonist and induces significant changes in 5-HT presynaptic receptor …

Feb 29, 2024 · This drug is in the serotonin-antagonist-and-reuptake-inhibitor class of medications; it can be used as a component of combination therapy with other drugs or …

Nov 7, 2014 · Trazodone is a multifunctional drug with dose-dependent pharmacologic actions. That is, it has hypnotic actions at low doses due to blockade of 5-HT 2A receptors, as well as …

“multifunctional” with a different mixture of pharmacologic functions, depending upon how high a dose is given. Trazodone’s most potent binding property is 5-HT2A antagonism.

The potent 5-HT agonist properties of the active metabolite m-CPP may play a role in the mechanism of action of trazodone. m-CPP inhibits serotonin reuptake and is a partial agonist …