CD1 (cluster of differentiation 1) is a family of glycoproteins expressed on the surface of various human antigen-presenting cells.

Dec 1, 2007 · This Review describes the journey taken by the MHC-class-I-like CD1 molecules, detailing their assembly, intracellular trafficking and loading with lipid antigens.

Cluster of differentiation 1 (CD1) is a family of cell-surface glycoproteins that present lipid antigens to T cells. Humans have five CD1 isoforms.

CD1 refers to a group of β2-microglobulin-associated proteins that are involved in the presentation of lipid antigens, with humans having four isoforms: CD1a, CD1b, CD1c, and CD1d.

Here, we solved lipidomes for the four human CD1 antigen-presenting molecules, providing a map of self-lipid display. Answering a basic question, the detection of >2,000 CD1-lipid complexes …

Sep 11, 2023 · In this review, we discuss the CD1-mediated antigen presentation system and its roles in mucosal tissue immunity.

This review summarizes the major features of CD1 genes and proteins, the patterns of intracellular trafficking of CD1 molecules, and how they sample different intracellular …

Jun 1, 2024 · While the biology and structure of CD1 molecules have been extensively investigated, it has recently become apparent that CD1 molecules can control immune …

CD1 is structurally and functionally similar to MHC class I and II molecules; however, CD1 presents lipids rather than polypeptides on antigen presenting cells. CD1 has also evolved a …

Whereas CD1 proteins were thought solely to influence T-cell responses through display of amphipathic lipids, recent studies emphasize the role of direct contacts between the T-cell …