The EMBO Journal

PV-1: a novel molecular prognostic marker of distant metastases in various solid tumors

PH proportional hazards, HR hazard ratio, CI confidence interval. a Per 10-unit increase. b Per 1-cm increase. c pT3 vs. pT1-2 (reference). d III-IV vs. I–II (reference). e Per 10-year increase. Bold ...
The EMBO Journal

Palmitoylation by ZDHHC4 inhibits TRPV1-mediated nociception

Transient receptor potential vanilloid 1 (TRPV1) is a capsaicin-sensitive ion channel implicated in pain sensation. While TRPV1 potentiation in hyperalgesia development has been extensively ...
The EMBO Journal

Identifying T-cell clubs by embracing the local harmony between TCR and gene expressions

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. T cell receptors (TCR) and gene expression ...
The EMBO Journal

Amplified centrosomes—more than just a threat

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...
The EMBO Journal

OXPHOS mutations and neurodegeneration

A jackal hunting mice at Etosha National Park, Namibia. The photographer, Hanna Kraus, is a PhD student at the Department of Molecular Evolution and Development of the University of Vienna. Her ...
The EMBO Journal

A ‘rich-get-richer’ mechanism drives patchy dynamics and resistance evolution in antibiotic-treated bacteria

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Global resource competition and local ...
The EMBO Journal

Molecular basis for maintenance of fidelity during the CCA‐adding reaction by a CCA‐adding enzyme

Here, we analysed nine binary complex structures of the class I AFCCA with nine mini‐helix variants, and two ternary complex structures of AFCCA with two mini‐helix variants and an incoming nucleotide ...
The EMBO Journal

Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The molecular mechanisms controlling the ...
The EMBO Journal

The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crz1p

Thus, Skn7p plays a part in numerous biological stress responses. In this paper we further elucidate a role for Skn7p in stress‐activated signal transduction. We present biochemical and genetic ...
The EMBO Journal

SCL/tal‐1‐dependent process determines a competence to select the definitive hematopoietic lineage prior to endothelial differentiation

In mouse embryos, the hematopoietic and vascular systems develop from the lateral mesoderm that exfoliates from the primitive streak between days 6.5 and 7.0 of gestation. Blood islands, the first ...
The EMBO Journal

New plastids, old proteins: repeated endosymbiotic acquisitions in kareniacean dinoflagellates

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Kareniacean plastids are distinct from those ...
The EMBO Journal

STINGing organelle surface with acid

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) innate immune pathway has emerged as a critical driver of inflammation in a variety of settings, such as virus infection, ...