Jacoby Brissett completed an NFL-record 47 passes, but San Francisco's offense rolled in Purdy's first game in weeks.

Oct 6, 2024; Santa Clara, California, USA; San Francisco 49ers tight end George Kittle (85) gestures after a catch against the Arizona Cardinals during the fourth quarter at Levi's Stadium. Mandatory Credit: Darren Yamashita-Imagn Images / Darren Yamashita-Imagn Images

San Francisco 49ers head coach Kyle Shanahan said he had big comebacks in mind when he kept Christian McCaffrey on the field with his team leading by 19 late in Sunday's game.

Five weeks after the San Francisco 49ers expected to have star wide receiver Brandon Aiyuk back from injury, the All-Pro wideout still has yet to be activated from the physically unable to perform list.

Former Pro Bowl RB LeSean McCoy believes the Arizona Cardinals point shaved in their Week 11 loss to the San Francisco 49ers.

The San Francisco 49ers quarterback finally returned to action, and his wife Jenna had the perfect look for their baby daughter to celebrate.

The 49ers head to State Farm Stadium to face the Arizona Cardinals with Brock Purdy back under center. Purdy was cleared off the injury report and is starting after missing six games with a turf-toe variant.

Ever since training camp last year, the San Francisco 49ers have been hit with one injury to a key player after another. They haven't gotten any type of respite from the injury bug, and it resulted in them going 6-11 and missing the playoffs last season after coming off a narrow loss in Super Bowl LVIII.