Programmed cell death 1 (PD-1, CD279, blue) immune checkpoint protein bound to programmed death-ligand 1 (PD-L1, red) protein, 3D rendering. PD-L1 is produced by tumors to suppress the immune system.

Scientists from Rutgers University and Brookhaven National Laboratory collaborated on this ongoing research and published a ...

Previous phase II and III bladder cancer trials of neoadjuvant chemotherapy alone or programmed cell death protein 1 (PD-1) alone have reported the pCR rate of between 30% and 42%. 4 With these ...

Response to programmed cell death protein 1 (PD-1) blockade is often conceptualized as resulting from reinvigoration of tumor-infiltrating lymphocytes. However, recruited antitumor immunity from the ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

Necroptosis is also a lytic form of programmed cell death initiated by pathogen infection, but it forms a protein complex called the necrosome. 10 The necrosome contains the mixed lineage kinase ...

University of Groningen. (2021, July 6). How an unfolding protein can induce programmed cell death. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2021 / 07 ...

Research presented in the August 2010 issue of Journal of Leukocyte Biology shows how interfering with the function of the cell membrane protein called "Programmed Death 1" improves survival in a ...

A collaborative study from the University of Cologne has uncovered how a key mitochondrial protein, AIFM1 (Apoptosis-Inducing ...

Apoptosis, or programmed cell death, may trace its origins to the time of mitochondrial domestication, suggesting remarkable conservation over the span of 1.8 billion years.

Programmed cell death protein 1 (PD-1) is a protein that is preferentially expressed in the body’s immune B, T, and NK cells.