Before the end of the first half, Brandon Aiyuk exited the Week 7 contest against the Kansas City Chiefs on a cart. Following the game, Kyle Shanahan told reporters that the 49ers are worried the start pass catcher has suffered an ACL injury.

: The 49ers have ruled out Brandon Aiyuk the rest of the game. They made the announcement to the media at the start of the third quarter. The San Francisco 49ers have lost wide receiver Brandon Aiyuk to a leg injury in Week 7.

Aiyuk suffered what appeared to be a right knee injury shortly before halftime in Week 7. After catching a pass for a gain of 15 yards, Aiyuk was crunched between Chamarri Conner and Trent McDuffie. He remained on the turf for a short time while being attended to by trainers.

San Francisco 49ers wide receiver Brandon Aiyuk might have suffered a significant injury in Sunday's loss to the Kansas City Chiefs. Head coach Kyle

The San Francisco 49ers lost standout receivers Brandon Aiyuk and Deebo Samuel during Sunday's 28-18 loss to the visiting Kansas City Chiefs.

San Francisco 49ers wide receiver Brandon Aiyuk was carted to the locker room after suffering a leg injury in their game against the Kansas City Chiefs.

Already missing one of their top three receivers, the 49ers ruled out Brandon Aiyuk (knee) and Deebo Samuel (illness) for the rest of Sunday's game against the Chiefs.

The San Francisco 49ers’ injury woes continued Sunday as receiver Brandon Aiyuk was carted into the locker room at the end of the first half, and ruled out for the remainder of the Chiefs game. Aiyuk suffered a leg injury with 48 seconds left in the second quarter.

The Kansas City Chiefs may be without wide receiver JuJu Smith-Schuster after he exited the defending champions' Week 7 matchup against the San Francisco 49ers with a hamstring injury. JuJu Smith-Schuster injury update Though Smith-Schuster was active and