The sodium-dependent glucose cotransporter SGLT1 undergoes a series of voltage- and ligand-induced conformational changes that underlie the cotransport mechanism. In this study we describe how the ...

This paper describes the design of a chip modeling the proximal renal tubule, namely the nephron segment that is most targeted by drug toxicants. The tubule model is based on a 3D convoluted geometry ...

Recently, however, studies using isolated, perfused tubules have established with certainty that aldosterone can regulate the transepithelial transport function of native renal tubules through ...

Discussion Our study investigated the impact of creatine supplementation on muscle GLUT4 content and glycogen and total creatine concentrations in healthy subjects during 2 weeks of voluntary leg ...

Gentamicin-induced nephrotoxicity is characterized by tubular necrosis mainly involving proximal tubules (23). It has been shown that oxidative stress is involved in gentamicin-induced renal damage ...

The proximal tubules in this condition appear short and poorly developed, with reduced convolution leading to reduced number of tubular profiles in histologic sections (8).

With tumor progression metabolism of the body is disturbed and toxic metabolites, entering the blood, can affect the structure of organs distant from tumor growth. The kidneys are one of the main ...

Creatine transporter deficiency (CTD) is an X-linked disease caused by mutations in the Slc6a8 gene. The impaired creatine uptake in the brain leads to developmental delays with intellectual ...