Programmed cell death 1 (PD-1, CD279, blue) immune checkpoint protein bound to programmed death-ligand 1 (PD-L1, red) protein, 3D rendering. PD-L1 is produced by tumors to suppress the immune system.

Response to programmed cell death protein 1 (PD-1) blockade is often conceptualized as resulting from reinvigoration of tumor-infiltrating lymphocytes. However, recruited antitumor immunity from the ...

A collaborative study from the University of Cologne has uncovered how a key mitochondrial protein, AIFM1 (Apoptosis-Inducing ...

PHILADELPHIA — A novel therapy targeting human programmed cell death protein-1 showed efficacy in rheumatoid arthritis with an attractive safety profile, according to a speaker at ACR ...

Background: All six programmed cell death-1 (PD-1) inhibitors (nivolumab, pembrolizumab, sintilimab, tislelizumab, toripalimab, and camrelizumab) have been used as first-line therapy in Chinese ...

Necroptosis is also a lytic form of programmed cell death initiated by pathogen infection, but it forms a protein complex called the necrosome. 10 The necrosome contains the mixed lineage kinase ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...

Cell Death & Differentiation - LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission Skip to main content Thank you for visiting nature.com.

Apoptosis, or programmed cell death, may trace its origins to the time of mitochondrial domestication, suggesting remarkable conservation over the span of 1.8 billion years.

Programmed cell death protein 1 (PD-1) is a protein that is preferentially expressed in the body’s immune B, T, and NK cells.