United have Alexander Isak available, something which Newcastle goalscoring hero Alan Shearer feels will be vital, but are without Kieran Trippier, while Callum Wilson looks set to again miss out.
Both Fabian Hurzeler's visitors and Eddie Howe's hosts have 3-3-1 records but the journeys of Brighton and Newcastle to get to 12 points have been markedly different this young Premier League season.
Some results have been hidden because they may be inaccessible to you