The model has been able to closely recapitulate human in vivo proximal tubule functionality and generated valuable insights regarding drug transport by primary human kidney cells.

Creatinine is present in the bloodstream (serum creatinine) and is filtered out of the body at a constant rate by the kidneys (glomerulus and the proximal tubule).

A 3D vascularized proximal tubule module enables the study of renal absorption, a key aspect of drug development and disease modeling.

This successfully maintains transporter expression, replicating the mechanisms of drug excretion in renal proximal tubules in vitro, mimicking the function of human epithelial tissue.

The identification of this second cystine transporter in proximal tubules has answered long-lasting mystery regarding cystine reabsorption.

This successfully maintains transporter expression, replicating the mechanisms of drug excretion in renal proximal tubules in vitro, mimicking the function of human epithelial tissue.

A 2023 study highlights the potential role of the organic anion transporter in the proximal tubules, suggesting that hydrophobic β-lactams may exacerbate mitochondrial stress induced by ...

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1.

And these tubules are tiny: There are proximal tubules inside each of the million-plus nephrons within a human kidney.