Key Takeaways Creatine monohydrate supplements raised serum creatine values in Alzheimer's disease patients in a pilot trial.

SGLT2 Interacts With Multiple Apical Proximal Tubule Metabolite Transporters To determine whether the changed proteins interact directly with SGLT2, we performed interactome analysis of the SGLT2 ...

The Newcells aProximateTM near-physiological kidney transporter model provides cross-species comparison of drug handling.

This successfully maintains transporter expression, replicating the mechanisms of drug excretion in renal proximal tubules in vitro, mimicking the function of human epithelial tissue.

Creatine may enhance brain energy, potentially combating fatigue, cognitive decline, dementia, and more. Here's how.

Proximal tubule. This filtering system is the first part of a tubule that captures nutrients and sends them back into the blood through the peritubular capillaries. Afferent arteriole.

Acute elevation of serum creatinine when initiating first-generation crizotinib may not be a reflection of true kidney injury, but rather a pseudo-kidney injury due to creatinine transporter ...

Selpercatinib leads to pseudo-decreased kidney function, which impairs tubular creatinine excretion. Cystatin C has no tubular secretion and may be a better marker for managing selpercatinib ...

Because animal models cannot directly assess the effect of serum components on tubules, researchers examined the effects of serum protein exposure in human kidney tubule neurophysiologic systems and ...

Human-immortalized renal proximal tubule epithelial cells (RPTECs-TERT1) were cultured on Matrigel to support the formation of 3D proximal tubular-like structures with the incorporation of a ...