Chronic kidney disease (CKD) is typically associated with severe fibrosis, the exact pathogenesis of which remains unclear.

An organic anionic drug (or drug metabolite) is taken up by OAT1 and/or OAT3 in the basolateral membrane of the proximal tubule cell via the tertiary transport mechanism mentioned above.

Discussion Our study investigated the impact of creatine supplementation on muscle GLUT4 content and glycogen and total creatine concentrations in healthy subjects during 2 weeks of voluntary leg ...

Thus, the results of the present study provide direct evidence that NHE3 in the proximal tubules physiologically promotes proximal tubule Na + transport and maintains basal blood pressure homeostasis ...

Extracellular vesicles have emerged as promising tools in regenerative medicine due to their inherent ability to facilitate intercellular communication and modulate cellular functions. These nanosized ...

With tumor progression metabolism of the body is disturbed and toxic metabolites, entering the blood, can affect the structure of organs distant from tumor growth. The kidneys are one of the main ...

Recently, however, studies using isolated, perfused tubules have established with certainty that aldosterone can regulate the transepithelial transport function of native renal tubules through ...