The aProximateTMinvestigates renal drug transport modalities and drug interactions in vitro. Skip to content. Menu. Medical Home Life Sciences Home. Become a Member. Search. Medical Home; ...

As evidenced by the loss of transporter and metabolic enzymes involved in drug transport and metabolism, primary kidney proximal tubule cells tend to dedifferentiate and lose important phenotypes ...

Fluid transport in the proximal tubule (i.e., ... (plasma creatinine level, 1.4 mg per deciliter [124 μmol per liter]) but had had normal kidney function at 58 years of age ...

These transporters control glucose transport and reabsorption in several tissue types, including the proximal renal tubule, small intestine, blood-brain barrier, and peripheral tissues . 13,16 ...

Efficient proximal tubule-on-chip model from hiPSC-derived kidney organoids for functional analysis of renal transporters. iScience , 2024; 27 (9): 110760 DOI: 10.1016/j.isci.2024.110760 Cite This ...

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1. Proceedings of the National Academy of Sciences , 2016 ...

Every day our kidneys tackle the daunting task of continuously cleaning our blood to prevent waste, salt and excess fluid from building up inside our bodies. To achieve this, the kidneys’ ...

For example, the kidney's proximal tubules are essential for reabsorbing critical substances from the bloodstream before urine formation. However, traditional in vitro models have struggled to ...

An international research group clarified that AGT1/SLC7A13, a membrane protein in kidneys, is identified as a transporter protein involved in renal reabsorption of cystine. AGT1 is an unknown ...

If you thought 3-D printing was just for fun—for making, say, a Batsuit—this video shows how researchers at Harvard’s Wyss institute have figured out a ...