The Houston Astros suffered a major loss on a night they notched a series win over the Chicago White Sox. Despite winning the game 4-3, third baseman Isaac Paredes was forced to leave early due to an apparent leg injury.

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Duran (4-2) walked Christian Walker with one out in the ninth and he moved to third on a two-out single by Jake Meyers. Smith then singled on a grounder to center to score Meyers for his first career walkoff hit and Houston's fourth straight victory.

Bryan Abreu and Kaleb Ort came in to finish the game after Framber’s night was finished and they did just that, with Abreu striking out two in the eighth, to help finish a 8-2 win. Ort did get in a little bit of trouble in the bottom of the ninth, allowing two runners, but he came back with two strikeouts and a groundout to end the game.

It's not easy for rookies to thrive in the big leagues, and Houston Astros outfielder Jacob Melton is learning that the hard way. The 24-year-old entered Friday's game against the Minnesota Twins, slashing .185/.241/.185 with three RBI over 10 contests.

It was only two weeks ago that left-hander Framber Valdez threw an 83-pitch complete game against the Rays, tying the club record for the fewest pitches by an Astros pitcher in a complete game since pitch-count tracking began in 1988.

Although the Houston Astros (38-30) hold a four and a half game lead in the American League West, they still do not look quite like themselves at this point of the 2025 MLB season. The lineup is specifically an enigma,

Mike Tauchman homered in the ninth, but the Chicago White Sox couldn’t complete the comeback in a 4-3 loss to the Houston Astros on Thursday.

The Chicago White Sox (23-44) and the Houston Astros (36-30) play the second game of a 3-game series Wednesday. First pitch from Daikin Park in Houston is scheduled for 8:10 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the White Sox vs. Astros odds and make our expert MLB picks and predictions for the best bets.