Can brain amyloid reduction be used as a surrogate biomarker of clinical benefit? This is a hotly debated question in the field (see Dec 2024 discussion). A recent post hoc analysis of Phase 3 ...
Comments For TDP-43 Aggregates, Breaking Up Is No Longer Hard to Do 13 May 2026 ...
The world did not end today as predicted, but unfortunately we have to report that development of another potential drug did. Allon Therapeutics Inc. announced 19 December that its drug candidate ...
The U.S. Food and Drug Administration has delayed a decision on a subcutaneous starting dose for Eisai and Biogen’s amyloid antibody lecanemab. The agency had accepted the company’s supplemental ...
Gareth Thomas, Ph.D. Lewis Katz School of Medicine at Temple University Contact Information Gareth Thomas, Ph.D. Philadelphia, United States ...
On April 28, Aligning Science Across Parkinson’s, aka ASAP, a philanthropic initiative backed by the Sergey Brin Family Foundation and The Michael J. Fox Foundation for Parkinson’s Research, together ...
The Alzheimer’s field was rocked this week by allegations against Sylvain Lesné at the University of Minnesota, Minneapolis. Lesné stands accused of manipulating data images in multiple papers, ...
This database is a repository of normal genetic variability, designed to be a tool for researchers who study neurodegenerative disease. It contains whole-exome sequencing results from nearly 500 ...
It has been clear for a while that anti-amyloid antibodies can sweep plaque from the brain, but until now the question of whether this slows cognitive decline has remained hotly contended. Despite ...
Eisai and Biogen yesterday announced positive topline results from the Phase 3 Clarity trial of their anti-amyloid antibody lecanemab. The drug slowed decline on the primary endpoint, CDR-SB, by 27 ...
Transferrin-receptor shuttles distribute antibody cargo throughout the parenchyma, steering clear of ARIA-provoking vascular amyloid. Trontinemab is enrolling Phase 3 for early AD, announces plans for ...
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