For the 80 million people worldwide with celiac disease, the only treatment available is to cut grains like pasta and bread out of their lives. But researchers are hoping to change that with a new ...
Researchers at the Max Delbrück Center and the University of Oxford have found that a cellular housekeeping function called autophagy—by which cell components are broken down and recycled—plays a ...
CD8 + cytotoxic T lymphocytes (CTLs) serve as central effectors in cancer immunotherapy by directly eliminating tumor cells. However, current clinical therapies face significant limitations. These ...
Scientists have discovered that our specialized immune cells, called T cells, are what they eat -- their switch from functional to 'exhausted' depends on the switch from metabolizing acetate to ...
Rheumatoid arthritis (RA) is an autoimmune disease that affects millions worldwide and can have a devastating impact on patients' lives. Yet, about one in three patients respond poorly to existing ...
Phase 1 study of LB1410, a bivalent TIM-3/PD-1 bispecific antibody, in patients with advanced solid tumors or lymphoma. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This ...
Killer immune cells destroy cancer cells and cells infected by virus. These CD8 + T cells are activated after detection of viral infection or growth of “non-self” tumor cells. However, in chronic ...
Data presented at ASH 2025 suggest earlier-line use of cilta-cel leads to better outcomes in multiple myeloma because patients have fitter immune systems and less exhausted T cells, improving CAR T ...
Reducing calorie intake in mouse tumour models improves anticancer immunity by enhancing metabolic and cytotoxic functions of specific immune cells, reports a new study published in the journal Nature ...
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