A double-strand break (DSB) is a type of DNA damage where both strands of the DNA helix are cut or broken at the same location, causing a complete discontinuity in the DNA molecule. Unrepaired or ...
The protooncoprotein N-Myc, which is overexpressed in approximately 25% of neuroblastomas as the consequence of MYCN gene amplification, has long been postulated to regulate DNA double-strand break ...
Insights could not only pave the way for new treatment strategies for genetic disorders, cancer and neurodegenerative diseases, but also enhance gene-editing technologies.
BRCA1 and BRCA2 genes play a crucial role in repairing damaged DNA. Mutations in BRCA1 and BRCA2 substantially increase the likelihood of breast and ovarian cancer, respectively. This new research ...
New study shows that in women with BRCA1 or BRCA2 mutations, their breast cells already carry a clear pattern of DNA “damage ...
An illustration of light purple Cas9 enzyme being guided to light blue DNA against dark blue background. The enzyme Cas9 (top) can cause double-strand breaks in DNA (bottom). Credit: Shutterstock ...
Morning Overview on MSN
New CRISPR technique flips genes on without cutting DNA
Researchers have unveiled a way to flip genes back on without slicing into the genome, a shift that could make CRISPR far ...
Broken String Biosciences launched an early access program (EAP) through which select developers of gene edited therapeutics will be able to use Broken String’s INDUCE-seq ® technology in their own ...
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