The structure and function of synapses are highly heterogeneous, even among synapses formed on single neuron 1,2,3. At the same time, pre- and postsynaptic structures and functions are well ...
Little is known about presynaptic assembly during central nervous system synaptogenesis. Here we used time-lapse fluorescence imaging, immunocytochemistry and electron microscopy to study hippocampal ...
Sitt Wai Fong, Ian S. McLennan, Andrew McIntyre, Jayne Reid, Kathleen I. J. Shennan, Guy S. Bewick, Lynn T. Landmesser Proceedings of the National Academy of Sciences of the United States of America, ...
Helping certain genetic information travel to specific parts of nerve cells can ease motor symptoms in SMA, a study in mice ...
Many studies link tau to synaptic dysfunction and memory loss in Alzheimer’s disease and other dementias. But how does tau do its dirty work? Most previous research focused on the harmful effects of ...
Researchers from the University of Tokyo reveal how the presynaptic Ube3a E3 ligase, a causal factor in Angelman syndrome, eliminates neural chat. The study helps find a better drug target for the ...
Miscreant forms of tau are known to start trouble when they wander away from axons and into presynaptic terminals. In the February 1 Neuron, researchers report that the synaptic vesicle protein ...
Selective serotonin reuptake inhibitors (SSRIs) work by increasing the levels of a substance called serotonin in the brain. Serotonin is a chemical messenger or a neurotransmitter. These messengers ...
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