A major factor in coronavirus disease 2019 (COVID-19)-associated mortality is the development of coagulation abnormalities that may result in thromboembolism. Human platelets have been found by ...

Boston, MA - A new report from the Framingham Offspring Study adds to the understanding of how alcohol can act as an anticoagulant [1]. It seems that it affects both platelet aggregation and ...

What Is the Platelet Aggregation Test? A platelet aggregation test is a blood test that looks at how well your blood cells called platelets clump together and clot. It is sometimes called a platelet ...

Platelets play an important role in atherothrombotic disease. The currently available antiplatelet drugs target key steps of platelet activation including thromboxane A 2 synthesis, ADP-mediated ...

Ado-trastuzumab emtansine (T-DM1) treatment results in grade 3-4 thrombocytopenia in 8%-13% of patients. Prior in vitro studies reported T-DM1 inhibition of megakaryocyte maturation as the cause of ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) bears an abundance of the characteristic spike protein, which mediates its entry into and fusion with the host cell, as well as ...

Megakaryocytes, which are derived from hematopoietic stem cell precursors in bone marrow, form and release platelets; these circulate in the blood for 8 to 10 days before they are removed by hepatic ...

The 5' nucleotidase protein apyrase is found in the saliva of all blood feeding arthropods (and an analogue in Vampire bats and leeches). Apyrases are enzymes that degrade ATP and ADP to AMP and ...

Diminished platelet autophagy potentially contributes to thrombocytopenia in cirrhotic patients. H 2 S modulates platelet autophagy and functions possibly via the PDGFR-α/PI3K/Akt/mTOR signaling ...

Platelet function may aid in determining disease severity for patients with psoriasis who are at an increased risk of developing cardiovascular disease (CVD) and increased inflammation, a review notes ...