Partition coefficients and solubility are fundamental parameters in the study of organic compounds, characterising the distribution of molecules between immiscible solvents. These properties are ...

Objectives The partitioning of lipophilic toxicants into blood and into adipose tissue plays an important role in the physiological distribution and toxicology of these substances. The partition ...

This is a preview. Log in through your library . Abstract The history of the relationship of biological activity to partition coefficient and related properties is briefly reviewed. The dominance of ...

BMC Clin Pharmacol. 2010;10:1-27. It is assumed that the tissue consists of N capillaries/cm 3, all with exactly the same geometry, blood flow, permeability, etc. It is also assumed that the relation ...