A major challenge in neuroscience is to understand how brain functions are mediated by particular cell types within neural networks. Dissection of such complex networks requires the ability to ...

Transgenic mice have become a staple in the study of basic biology and disease, including Alzheimer's. Even so, the method predominantly used today to create these animals remains technically ...

Until recently, research in prairie voles, as with many species other than the laboratory mouse, has been based largely on behavioral and pharmacological manipulation. While this line of research in ...

The problem with transgenic mouse models of human disease is just that — they are mouse models. And although they can be very useful, the many differences between us and mice have proved problematic ...