Bacterial pathogens have evolved diverse strategies to manipulate host cells to establish infection. At a molecular level, this is often mediated by virulence factors that are secreted into host cells ...

Supercomputer simulations have revealed how changes in the shape of the HIV-1 capsid protein may help the virus squeeze its inner core into the host cell's nuclear membrane. The findings, by a ...

Large molecule biotherapeutics are primarily expressed and produced in mammalian host cells then purified from complex mixtures containing growth media and host cell material. Identifying, monitoring, ...

A research team at the University of Greifswald's Research Training Group RTG-PRO "Proteases in pathogen and host: importance ...

Viruses are microscopic pathogens composed of genetic material housed within a protective protein shell. While they carry the blueprint required for producing additional viral proteins, they lack the ...

Researchers at the Francis Crick Institute have shown that the Cryptosporidium parasite exports a protein into infected intestinal cells, altering the gut environment and enabling the parasite to ...

Pseudomonadota (formerly Proteobacteria) are prevalent in the commensal human gut microbiota, but also include many pathogens that rely on secretion systems to support pathogenicity by injecting ...

A new study reveals the biological secret to the Zika virus's infectious success: Zika uses host cells' own 'self-care' system of clearing away useless molecules to suppress the host proteins that the ...

Making proteins for research or therapies often starts with cell-line development. In many applications, genetic engineering is used to optimize a cell line for producing high levels of the intended ...

Viruses have evolved various strategies to coexist and replicate within host cells. Mimicry of host proteins represents a key mechanism that ensures the prolonged persistence of herpesviruses in host ...