This article explores a number of frequently asked questions around working with plateable hepatocytes. It also outlines common reasons that hepatocyte plating fails, providing a range of potential ...

This article is based on a poster originally authored by Chris Bohl, Ken Brouwer, Karissa Cottier, Scott Heyward, Courtney Noah, Brian Ogilvie, and BioIVT. Several reports in the literature have ...

(A) Distinct phases of APAP-ALF. (B) Integrative multimodal approaches, including single-nucleus RNA sequencing spatial transcriptomics, four-dimensional intravital imaging and lineage tracing in both ...

The liver has a unique structure, especially at the level of individual cells. Hepatocytes, the main liver cells, release bile into tiny channels called bile canaliculi, which drain into the bile duct ...

Understanding how a potential drug is metabolised in the liver is a critical first step in early-stage drug development - but ...

When harnessing immune cells to fight cancer, researchers traditionally focused on T cells or natural killer cells circulating through the blood. However, the critical cell types coordinating this ...

Biliary atresia (BA) is a life-threatening liver disease of infancy in which early surgery can restore bile flow but rarely ...

What am I looking at? This is a single human hepatocyte. Its two nuclei are in blue (1). The other colors in this image are stains of the actin protein and are depth-coded, with red being the closest ...