A number of membrane proteins that are present on the cell membrane control external and internal material transportation, cell protection and signal transmission. The diversity of functions of ...

G protein-coupled receptors (GPCRs) are expressed on the surface of cells and regulate a range of important functions. Because they are involved in so many sensory and physiological processes, ...

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G protein-coupled receptors (GPCRs). This research offers ...

G protein-coupled receptors (GPCRs) constitute one of the largest families of membrane proteins and play a pivotal role in translating extracellular signals into diverse intracellular responses. A key ...

A recent study published in Nature by a research team from the United States and China introduced a new class of engineered G ...

B-cell maturation antigen (BCMA)–directed chimeric antigen receptor (CAR) T-cell therapies have generated responses in patients with advanced myeloma, but relapses are common. G protein–coupled ...

The interplay between G protein-coupled receptors (GPCRs) and fatty acid metabolism is emerging as a pivotal aspect in the pathogenesis and treatment of type 2 diabetes. Receptors such as free fatty ...

About one-third of all drugs approved by the Food and Drug Administration target the largest family of cell membrane ...

We are working on medicines* to fulfill unmet needs. We believe that small-molecule therapies targeting G-protein-coupled receptors (GPCRs) have the potential to transform the lives of patients with ...

A publication from Acta Pharmaceutica Sinica B discusses allosteric modulation of G protein-coupled receptors as a novel therapeutic strategy in neuropathic pain. Neuropathic pain is a debilitating ...

Seeking students to join a new and growing lab that seeks to understand the molecular causes of cancer in order to develop better therapies and improve patient outcomes. Our lab seeks to understand ...

A collaborative research group has developed a novel therapeutic candidate that may improve the prognosis of severe cutaneous ...