ascopubs.org

Cyclooxygenase-2 and Epidermal Growth Factor Receptor: Pharmacologic Targets for Chemoprevention

Evidence is presented that cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) are potential pharmacologic targets to prevent cancer. In this paper, we review key data implicating a ...
Nature

Inducible cyclooxygenase may have anti-inflammatory properties

Figure 1: Correlation between inflammation, COX 2 expression, COX activity and PGE 2 levels in carrageenin-induced pleurisy. Figure 2: Effects of COX inhibitors on inflammatory exudate volume and ...
JSTOR Daily

COX-3, a Cyclooxygenase-1 Variant Inhibited by Acetaminophen and Other Analgesic/Antipyretic Drugs: Cloning, Structure, and Expression

N. V. Chandrasekharan, Hu Dai, K. Lamar Turepu Roos, Nathan K. Evanson, Joshua Tomsik, Terry S. Elton, Daniel L. Simmons Proceedings of the National Academy of ...
EurekAlert!

Inhibition of cyclooxygenase-2 upregulates the nuclear factor erythroid 2-related factor 2 signaling pathway to mitigate hepatocyte ferroptosis in chronic liver injury

Ferroptosis plays an essential role in chronic liver diseases, and cyclooxygenase-2 (COX-2) affects liver fibrosis through multiple mechanisms. However, research on COX-2 regulation of ferroptosis in ...
ascopubs.org

Cyclooxygenase inhibition and response to anti-PD1/L1 in advanced melanoma.

Dose-response evaluation of brocolli sprout extract sulforaphane (BSE-SFN) in melanoma patients (Pts) with atypical/dysplastic nevi (A/DN). This is an ASCO Meeting Abstract from the 2016 ASCO Annual ...