The aProximateTMinvestigates renal drug transport modalities and drug interactions in vitro. Skip to content. Menu. Medical Home Life Sciences Home. Become a Member. Search. Medical Home; ...

Creatinine is present in the bloodstream (serum creatinine) and is filtered out of the body at a constant rate by the kidneys (glomerulus and the proximal tubule). Image Credit: Shidlovski ...

Although the observed elevations in serum creatinine during combination therapy have ... A 2023 study highlights the potential role of the organic anion transporter in the proximal tubules, ...

Every day our kidneys tackle the daunting task of continuously cleaning our blood to prevent waste, salt and excess fluid from building up inside our bodies. To achieve this, the kidneys’ ...

Novel cystine transporter in renal proximal tubule identified as a missing partner of cystinuria-related plasma membrane protein rBAT/SLC3A1. Proceedings of the National Academy of Sciences , 2016 ...

Efficient proximal tubule-on-chip model from hiPSC-derived kidney organoids for functional analysis of renal transporters. iScience , 2024; 27 (9): 110760 DOI: 10.1016/j.isci.2024.110760 Cite This ...

For example, the kidney's proximal tubules are essential for reabsorbing critical substances from the bloodstream before urine formation. However, traditional in vitro models have struggled to ...

An international research group clarified that AGT1/SLC7A13, a membrane protein in kidneys, is identified as a transporter protein involved in renal reabsorption of cystine. AGT1 is an unknown ...

If you thought 3-D printing was just for fun—for making, say, a Batsuit—this video shows how researchers at Harvard’s Wyss institute have figured out a ...