Constraint models have been extremely useful in identifying the deleterious variants that underlie disease in the part of the genome in the cell nucleus. However, nuclear constraint models could not ...

We investigate risk-averse stochastic optimization problems with a risk-shaping constraint in the form of a stochastic-order relation. Both univariate and multivariate orders are considered. We extend ...

In this article, we derive second-order necessary conditions of optimality for an abstract optimization problem with equality and inequality constraints and constraints in the form of an inclusion ...