Both the Boston Celtics and Cleveland Cavaliers may be without multiple key players in Wednesday night's matchup.

The Boston Celtics host the Cleveland Cavaliers tonight in their first regular-season clash. Boston, struggling with a 1-4 record, faces a 3-1 Cavalie

Mitchell is the Cavs best player and he is playing very well so far this season. He is averaging 31.3 points, 2 rebounds, 3 assists, and 1.5 steals per game while shooting 56.4% from the field and 35.5% from beyond the arc. The Celtics need to defend him particularly well if they hope to win this game.

Boston Celtics star Jayson Tatum updated his social media followers on his injury recovery process on Tuesday.

For coach J.B. Bickerstaff, the start of the season is always exciting, particularly when his team is hosting a home opener.

The Celtics first win of the 2025-2025 season finally came on the road, four games into the season. This is not a good thing.

The Detroit Pistons leaned on their gritty play style to channel a tough comeback victory against the Boston Celtics

After two productive games to start the season, Williamson is listed as “questionable” for Monday’s game at Smoothie King Center against the Boston Celtics. Williamson is dealing with a bone contusion on his left foot. He wasn’t listed on the original injury report released by the team on Monday morning.

The Boston Celtics will tip off their 2025-26 campaign on Wednesday as they get set to take on the Philadelphia 76ers. More news: Celtics' Anfernee Simons Know

SportsLine's model simulated Boston vs. Cleveland 10,000 times and revealed its NBA predictions for Wednesday's matchup