Mitochondrial calcium signalling plays a fundamental role in cellular homeostasis by modulating energy production and activating key metabolic enzymes. Calcium ions (Ca2+) are dynamically exchanged ...
1don MSN
New ALS treatment target identified: STAUFEN-1 protein reduction protects brain cells from death
University of Utah researchers at the Pulst-Scoles Laboratory have discovered that reducing levels of the STAUFEN-1 protein ...
New research has discovered that reducing levels of the STAUFEN-1 protein can prevent neuron death caused by DNA damage and ...
The emergence of cancer drug resistance remains one of the most pressing problems in cancer care and there is a critical need to devise approaches to mitigate it. However, the molecular mechanisms ...
Itaconate, an endogenous mitochondrial metabolite produced by the enzyme aconitate decarboxylase 1 (ACOD1), has emerged as a central regulator of ...
When the cell's recycling stations, the lysosomes, start leaking, it can become dangerous. Toxic waste risks spreading and ...
A new study reveals how a single cancer protein may simultaneously drive tumor survival and metabolic control, uncovering a hidden link between two core features of cancer. Scientists have uncovered a ...
In an extensive review, researchers explore ZBP1-mediated programmed cell death and its potential as a therapeutic target for systemic diseases Programmed cell death, or PCD, is an actively regulated ...
Scientists discovered that certain cancer cells use a low-level activation of a DNA-dismantling enzyme—normally seen in cell death—to survive treatment. Instead of dying, these “persister cells” ...
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