PURPOSE: Angiogenesis, a process fundamental to tumor growth, is regulated by angiogenic factors. This article reviews prognostic and other clinical implications of circulating angiogenic factors in ...

Most tumors release various signaling molecules to support their incessant growth, invasion, and metastasis. Some of these molecules, known as tumor angiogenic factors (TAF), are able to stimulate the ...

Tumour heterogeneity leads to heterogeneity in the tumour vasculature. Just as there are multiple phenotypes for any given tumour type, so can there be multiple phenotypes of the tumour angiogenic ...

Although vascular endothelial growth factor (VEGF) is a primary mediator of retinal angiogenesis, VEGF inhibition alone is insufficient to prevent retinal neovascularization. Hence, it is postulated ...

Angiogenesis is a key player in the growth of cancer cells and metastasis of tumors, it can be considered both an attractive target and major challenge in the treatment of cancer. In this article, we ...

The cause of preeclampsia remains unclear. Limited data suggest that excess circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor (PlGF) and vascular endothelial ...

Angiogenesis is a fundamental process underlying the pathology of many diseases. It can be modeled in vitro using tube formation assays, in which endothelial cells are induced to form tube-like ...