George Kirby will keep the Padres' lineup off balance en route to a Mariners win, per our Padres vs. Mariners predictions and Sunday Night Baseball picks for May 17.

Gavin Sheets homered twice and drove in four runs, Lucas Giolito won his San Diego debut and the Padres beat the Seattle Mariners 8-3 to sweep their six-game season series.

The San Diego Padres scored seven runs off Mariners starter Logan Gilbert, including a trio of home runs, in a 7-4 Seattle loss on Saturday afternoon.

SportsLine's model simulated San Diego Padres vs. Seattle Mariners 10,000 times and revealed its MLB predictions and Sunday Night Baseball picks

Padres manager Craig Stammen confirmed Lucas Giolito will make his much-awaited Padres debut Sunday against the Mariners.

The San Diego Padres and Los Angeles Dodgers square off in their first series of the 2026 season. Both National League West teams are coming off clean sweeps of their respective opponents over the weekend in the Seattle Mariners and Los Angeles Angels.

The San Diego Padres and Los Angeles Dodgers are finally meeting for the first time this season.

The Dodgers have won five in a row and outscored the Angels 31-3 over three games in Anaheim over the weekend to maintain a half-game lead on the Padres in the division. The two-time defending World Series champs won nine of 13 meetings last year with San Diego.

FriarWatch: May 17 Edition