Syria was once among the closest allies of the Islamic republic, but the new government resents Tehran’s support for the Assad regime and has pledged not to allow attacks on Israel from its territory.

U.S. stock futures are lower after President Donald Trump abruptly left the Group of Seven summit in Canada. Trump had earlier urged everyone to immediately evacuate Tehran and reiterated that Iran should have signed a nuclear deal with the United States.

Since Israel began its concerted attack on Iran on Friday, calls for regime change in Iran have grown louder – from hawks in the US Congress to Israeli officials and some Iranian activists abroad.

The conflict has killed hundreds and wounded more than a thousand since Friday in Iran and killed at least 24 and injured hundreds in Israel. The attack on Iran came amid protracted talks between the U.S. and Iran centered around Iran’s nuclear program.

More detail: Trump has said for days that Iran should make a nuclear deal with the U.S. But his message became more dire as he warned the Iranian capital's roughly 10 million residents to flee in the dead of night.

In Iraqi airspace, Iranian missiles and drones have crossed paths with Israeli warplanes, forcing Baghdad to step up efforts to avoid being drawn into the region's latest conflict.But with Baghdad both an ally of Iran and a strategic partner of the United States,

Israel claimed that it took 48 hours to gain aerial superiority over western Iran, including Tehran. Israeli authorities say that so far, one-third of the Islamic Republic’s missile launchers have been destroyed.

By Alexander Cornwell and Parisa Hafezi TEL AVIV/DUBAI (Reuters) -Israel and Iran attacked each other for a fifth straight day on Tuesday, and U.S. President Donald Trump urged Iranians to evacuate Tehran,